Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches



Publisher: Springer

Written in English
Cover of: Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches |
Published: Pages: 238 Downloads: 10
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Subjects:

  • Cardiovascular medicine,
  • Medical / Nursing,
  • Medical,
  • Cardiology,
  • Surgery - Vascular,
  • Medical / Cardiology

Edition Notes

  Organ and tissue loss through disease and injury motivate the development of therapies that can regenerate tissues and decrease reliance on transplantations. Regenerative medicine, an interdisciplinary field that applies engineering and life science principles to promote regeneration, can potentially restore diseased and injured tissues and whole by:   Currently, there are two complementary theories about the process of intrinsic repair in the heart after an ischaemic injury: (1) cardiomyocytes re-enter the cell cycle and start the process of proliferation, regeneration and repair of the necrotic tissue; 11,12 and (2) certain endogenous cardiac stem cells undergo growth and differentiation Cited by:   Cardiovascular diseases Leading cause of death worldwide for both men and women. Treatment Limitations: restricted intrinsic regeneration capacity of the heart Cardiomyocytes (adult heart muscle cells) cannot divide to replace injured cells lack of organs for transplantation. Main Targets for Tissue Engineering Blood vessels Heart muscle. At present, cardiac diseases are a major cause of morbidity and mortality in the world. Recently, a cell-based regenerative medicine has appeared as one of the most potential and promising therapies for improving cardiac diseases. As a new generational cell-based regenerative therapy, tissue engineering is focused. Our laboratory has originally developed cell sheet-based scaffold-free tissue Cited by:

Our goals are to identify preoperative and postoperative biomarkers for transplant rejection and thereby guide individualized therapy for transplant recipients. Improving xenogeneic scaffolds. Many researchers are investigating methods of using animal tissues as tissue engineering scaffolds for development of tissue-engineered organs and tissues. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly.   REANIMA project may overturn paradigms that underlie regenerative cardiology research new therapies for heart regeneration." and human heart tissues generated by tissue engineering. Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally.

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches Download PDF EPUB FB2

In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap­ proaches.

In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap­ : Springer Japan.

Download Citation | Cardiovascular regeneration therapies using tissue engineering approaches | The fact that the cardiovascular system transports oxygen and nutrients to all parts of the body. Cardiovascular regeneration therapies using tissue engineering approaches.

[H Mori; Hikaru Matsuda;] -- "With input from many of the leading researchers and practitioners, this book describes techniques for therapeutic angiogenesis and vasculogenesis for the treatment of ischemic. Cell-based therapy and tissue engineering have become one of the most promising therapies for treating heart diseases.

Our laboratory has developed a scaffold-free tissue engineering, ‘cell sheet engineering’, and has already successfully applied this to cardiac tissue engineering and.

From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies.

Entdecken Sie "Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches" von Hidezo Mori und finden Sie Ihren Buchhändler. The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches book to organs, tissues, and cells.

Obstructive diseases of. Fujisato T. et al. () Preparation and Recellularization of Tissue Engineered Bioscaffold for Heart Valve Replacement.

In: Mori H., Matsuda H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering by:   This Review discusses the advances in therapeutic approaches for cardiac repair and regeneration, including cell-based therapies as well as the use of Cited by: Institute to promote cardiovascular regeneration therapies using such ap­ proaches.

Therefore, it is with the financial aid and support of research grants, such as that for Cardiovascular Disease (13C-1 and I6C-6), Health and Labor Sciences Research Grants (RHGTEFB-genome, RHGTEFB-saisei, and CRCD-junkanki) and a grant from NEDO. To protect the failing heart, scientists have recently focused on approaches to promote heart regeneration.

Initial approaches, the so-called first-generation cell- based therapies, involved transplanting noncardiac cells because researchers could not obtain adequate numbers of functional cardiomyocytes to replace the lost myocardium Cited by: Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge.

Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering.

Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy Manufacturer: Woodhead Publishing.

Regenerative medicine aims at the functional restoration of a damaged, malfunctioning, or missing tissue.

Three main approaches in Regenerative Medicine include 1) cell-based therapies, 2) “classical tissue engineering” using cells and a bio-degradable scaffold to form a tissue, and 3) material-based approaches which rely on bio-degradable materials, often functionalized with cellular.

Evolving Concepts for Use of Stem Cells and Tissue Engineering for Cardiac Regeneration: /ch The incidence of cardiovascular disease (CVD) in adults are increasing worldwide with impaired repair mechanisms, leading to tissue and organ failure.

WithAuthor: Jahnavi Sarvepalli, Rajalakshmi Santhakumar, Rama Shanker Verma. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy.

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical. Purchase Cardiac Regeneration and Repair - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. Tissue engineering and biomaterials, microvascular growth and remodeling, stem cell engineering The Botchwey Laboratory takes a multidisciplinary approach for improvement of tissue engineering therapies through study of microvascular remodeling, inflammation resolution and host stem cells.

Buy (ebook) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches by Hidezo Mori, Hikaru Matsuda, eBook format, from the Dymocks online bookstore. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and of Contents: Introduction / The HeartStructure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials -- Polymers, Scaffolds, and Basic Design Criteria.

A variety of engineering approaches have been applied to produce ECM-mimicking structures to promote cardiovascular tissue regeneration. Recently, stem cell-derived extracellular vesicles (EVs) have been extensively studied for treating diseases and disorders of many systems, such as the cardiovascular, neurological, musculoskeletal, and immune.

Tissue engineering applies the principles of engineering, material science, and biology toward the development of biological substitutes that restore, maintain, or improve tissue function. Progress has been made in engineering the various components of the cardiovascular system, including blood vessels, heart valves, and cardiac by: Cardiac tissue engineering and regeneration using cell-based therapy Mohammad T Alrefai,1–3 Divya Murali,4 Arghya Paul,4 Khalid M Ridwan,1,2 John M Connell,1,2 Dominique Shum-Tim1,2 1Division of Cardiac Surgery, 2Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada; 3King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Cardiac regeneration is a broad effort that aims to repair irreversibly damaged heart tissue with cutting-edge science, including stem cell and cell-free therapy. Reparative tools have been engineered to restore damaged heart tissue and function using the body's natural ability to regenerate.

Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to. Current therapies—adult stem and precursor cells. After promising preclinical results using adult stem and precursor cells for cardiac regeneration a rapid clinical translation using autologous bone marrow cells (BMCs) in patients was initiated (7,8).In the last few years numerous clinical trials addressing the transplantation of various adult stem cell populations for cardiac regeneration Cited by: Hence, the future challenge of cardiovascular therapies will be the functional regeneration of myocardial contractility by novel concepts, like cell based therapy, tissue engineering or reprogramming of scar fibroblasts (5,6).

Current therapies—adult stem and precursor cells. use the terms regenerative medicine and tis-sue engineering, we group these activities to-gether in this review under the heading of regenerative medicine.

Therapies in the Market Since tissue engineering and regenerative medicine emerged as an industry about two decades ago, a number of therapies have re-ceived Food and Drug Administration (FDA)Cited by: Keywords:Cardiac regeneration, endogenous cell populations, paracrine factors, stem cell therapy, tissue engineering.

Abstract:After myocardial infarction, the lost healthy myocardium is replaced by non-contractile scar tissue which may lead to the development of heart failure and death. There is no curative therapy for the irreversible Cited by: 4.

title = "Therapeutic approaches for cardiac regeneration and repair", abstract = "Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar by:   The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering.

The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs.The main goal of the Cardiovascular Tissue Engineering Laboratory, under the direction of Erik Suuronen, PhD, is to develop tissue engineering and cell-based therapeutic approaches for the treatment of cardiac injury and disease.

Despite major advances in therapy, there are still a significant number of patients identified with the coronary artery disease who die of it. This is because over.